Homo sapiens Gene: BBC3
InnateDB Gene IDBG-59341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BBC3
Gene Name BCL2 binding component 3
Species Homo sapiens
Ensembl Gene ENSG00000105327
Encoded Proteins
BCL2 binding component 3
BCL2 binding component 3
BCL2 binding component 3
BCL2 binding component 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47220822-47232766
Strand Reverse strand
Band q13.32
ENST00000341983 ENSP00000341155
ENST00000300880 ENSP00000300880
ENST00000439096 ENSP00000395862
ENST00000449228 ENSP00000404503
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 17 [view]
Protein-DNA 8 [view]
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006915 apoptotic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0008340 determination of adult lifespan
GO:0032464 positive regulation of protein homooligomerization
GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration
GO:0034976 response to endoplasmic reticulum stress
GO:0043525 positive regulation of neuron apoptotic process
GO:0045926 negative regulation of growth
GO:0051209 release of sequestered calcium ion into cytosol
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070245 positive regulation of thymocyte apoptotic process
GO:0071456 cellular response to hypoxia
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097190 apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001244 positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
No orthologs found for this gene
Activation of PUMA and translocation to mitochondria pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members pathway
Intrinsic Pathway for Apoptosis pathway
p53 signaling pathway pathway
Huntington's disease pathway
Direct p53 effectors
p73 transcription factor network
Validated transcriptional targets of TAp63 isoforms
SwissProt Q96PG8 Q9BXH1
UniProt Splice Variant
Entrez Gene 27113
UniGene Hs.467020
RefSeq NM_001127240 NM_001127241 NM_001127242 NM_014417 XM_005258740 XM_006723141
OMIM 605854
CCDS CCDS12697 CCDS46128 CCDS46129 CCDS46130
EMBL AC008532 AF332558 AF354654 AF354655 AF354656 AK298837 BC136481 CH471126 U82987
GenPept AAB51243 AAI36482 AAK31316 AAK39542 AAK39543 AAK39544 BAG60965 EAW57465 EAW57467
RNA Seq Atlas 100422832 100422899 27113