Version 5.4
Homo sapiens Gene: FBXO21
Summary
InnateDB Gene IDBG-59432.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO21
Gene Name F-box protein 21
Synonyms FBX21
Species Homo sapiens
Ensembl Gene ENSG00000135108
Encoded Proteins
IDBP-59436
F-box protein 21
IDBP-383822
F-box protein 21
IDBP-604370
F-box protein 21
IDBP-604371
F-box protein 21
IDBP-812305
F-box protein 21
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:117141988-117190531
Strand Reverse strand
Band q24.22
Transcripts
ENST00000330622 ENSP00000328187
ENST00000427718 ENSP00000414468
ENST00000550180 ENSP00000449264
ENST00000547806
ENST00000548840 ENSP00000446973
ENST00000549689
ENST00000551458
ENST00000622495 ENSP00000483508
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032898
View Gene Order
ENSBTAG00000032097
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.602990 Hs.740376
RefSeq NM_015002 NM_033624
HUGO
OMIM
CCDS CCDS44989 CCDS9184
HPRD 09948
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca