Homo sapiens Gene: ST3GAL5
Summary
InnateDB Gene IDBG-59513.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL5
Gene Name ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Synonyms SATI; SIAT9; SIATGM3S; ST3GalV;
Species Homo sapiens
Ensembl Gene ENSG00000115525
Encoded Proteins
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:85839144-85889014
Strand Reverse strand
Band p11.2
Transcripts
ENST00000377332 ENSP00000366549
ENST00000306262 ENSP00000306247
ENST00000393808 ENSP00000377397
ENST00000393805 ENSP00000377394
ENST00000455892 ENSP00000401375
ENST00000433665 ENSP00000408635
ENST00000461206
ENST00000487896
ENST00000473122
ENST00000461892
ENST00000461199
ENST00000484728
ENST00000490946
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004513 neolactotetraosylceramide alpha-2,3-sialyltransferase activity
GO:0008373 sialyltransferase activity
GO:0047291 lactosylceramide alpha-2,3-sialyltransferase activity
Biological Process
GO:0001574 ganglioside biosynthetic process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0006688 glycosphingolipid biosynthetic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Post-translational protein modification pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Sialic acid metabolism pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
KEGG
Glycosphingolipid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UNP4
TrEMBL C9JYS9 E7EPY0 F8WEA8
UniProt Splice Variant
Entrez Gene 8869
UniGene Hs.736775
RefSeq NM_001042437 NM_003896
HUGO HGNC:10872
OMIM 604402
CCDS CCDS1986 CCDS42705
HPRD
IMGT
EMBL AB018356 AC105053 AF105026 AF119415 AK001340 AY152815 AY359105 BC065936 CH471053
GenPept AAD14634 AAF66146 AAH65936 AAO16866 AAQ89463 AAY24147 BAA33950 BAG50894 EAW99475 EAW99479
RNA Seq Atlas 8869