InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TRPC1

Summary

InnateDB Gene

IDBG-59714.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRPC1

Gene Name

transient receptor potential cation channel, subfamily C, member 1

Synonyms

HTRP-1; TRP1

Species

Homo sapiens

Ensembl Gene

ENSG00000144935

Encoded Proteins

IDBP-59716

transient receptor potential cation channel, subfamily C, member 1

IDBP-479095

transient receptor potential cation channel, subfamily C, member 1

IDBP-483942

transient receptor potential cation channel, subfamily C, member 1

IDBP-813807

transient receptor potential cation channel, subfamily C, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:142724074-142807888

Strand

Forward strand

Band

q23

Transcripts

ENST00000273482	ENSP00000273482
ENST00000476941	ENSP00000419313
ENST00000460401	ENSP00000418708
ENST00000480101
ENST00000612385	ENSP00000481537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015279	store-operated calcium channel activity
GO:0044325	ion channel binding
GO:0070679	inositol 1,4,5 trisphosphate binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007411	axon guidance
GO:0034220	ion transmembrane transport
GO:0046541	saliva secretion
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol
GO:0051480	cytosolic calcium ion homeostasis
GO:0051592	response to calcium ion
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0030017	sarcomere
GO:0043034	costamere
GO:0043234	protein complex
GO:0043235	receptor complex
GO:0045121	membrane raft