Homo sapiens Gene: SYT12
Summary
InnateDB Gene IDBG-59801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT12
Gene Name synaptotagmin XII
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173227
Encoded Proteins
synaptotagmin XII
synaptotagmin XII
synaptotagmin XII
synaptotagmin XII
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67006778-67050863
Strand Forward strand
Band q13.2
Transcripts
ENST00000393946 ENSP00000377520
ENST00000525457 ENSP00000431400
ENST00000527043 ENSP00000435316
ENST00000526281
ENST00000531392
ENST00000533427 ENSP00000434709
ENST00000525149
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030672 synaptic vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q8IV01
TrEMBL E9PNM5 Q8NDM9
UniProt Splice Variant
Entrez Gene 91683
UniGene Hs.287636
RefSeq NM_001177880 NM_177963 XM_006718737
HUGO HGNC:18381
OMIM 606436
CCDS CCDS8154
HPRD 07337
IMGT
EMBL AL833834 AP000729 AP003176 BC037406
GenPept AAH37406 CAD38694
RNA Seq Atlas 102725335 91683