Homo sapiens Gene: ADRBK1
Summary
InnateDB Gene IDBG-59896.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRBK1
Gene Name adrenergic, beta, receptor kinase 1
Synonyms BARK1; BETA-ARK1; GRK2;
Species Homo sapiens
Ensembl Gene ENSG00000173020
Encoded Proteins
adrenergic, beta, receptor kinase 1
adrenergic, beta, receptor kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Fibrates protect against bacteria‚?źinduced sepsis by inhibiting LPS‚?źmediated ERK phosphorylation and the expression of Adrbk1 (GRK2), thereby preventing Cxcr2 down-regulation on neutrophils.
Entrez Gene
Summary The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67266410-67286556
Strand Forward strand
Band q13.2
Transcripts
ENST00000308595 ENSP00000312262
ENST00000416281
ENST00000526285 ENSP00000434126
ENST00000530291
ENST00000529738
ENST00000533077
ENST00000534651
ENST00000532099
ENST00000526572
ENST00000527176
ENST00000529815
ENST00000531390
ENST00000532611
ENST00000524899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 58 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 58 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004703 G-protein coupled receptor kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0031694 alpha-2A adrenergic receptor binding
GO:0031755 Edg-2 lysophosphatidic acid receptor binding
GO:0047696 beta-adrenergic receptor kinase activity
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway
GO:0003108 negative regulation of the force of heart contraction by chemical signal
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007213 G-protein coupled acetylcholine receptor signaling pathway
GO:0007217 tachykinin receptor signaling pathway
GO:0007507 heart development
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0031623 receptor internalization
GO:0033605 positive regulation of catecholamine secretion
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0045087 innate immune response
GO:0045988 negative regulation of striated muscle contraction
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
Hedgehog pathway
FSH pathway
REACTOME
Signaling by FGFR in disease pathway
CaM pathway pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Phospholipase C-mediated cascade pathway
DAP12 signaling pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
PLC-gamma1 signalling pathway
Opioid Signalling pathway
DAG and IP3 signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Immune System pathway
Downstream signal transduction pathway
NGF signalling via TRKA from the plasma membrane pathway
Signaling by FGFR pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Ca-dependent events pathway
Calmodulin induced events pathway
Disease pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
INOH
Hedgehog signaling pathway pathway
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Role of √?-arrestins in the activation and targeting of map kinases [Biocarta view]
Ss-arrestins in gpcr desensitization [Biocarta view]
Regulation of ck1/cdk5 by type 1 glutamate receptors [Biocarta view]
Roles of √? arrestin dependent recruitment of src kinases in gpcr signaling [Biocarta view]
PID NCI
CXCR4-mediated signaling events
IL8- and CXCR1-mediated signaling events
Signaling events mediated by HDAC Class II
Signaling events mediated by the Hedgehog family
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.624006 Hs.83636
RefSeq NM_001619
HUGO
OMIM
CCDS CCDS8156
HPRD 00182
IMGT
EMBL
GenPept
RNA Seq Atlas