Homo sapiens Gene: CHKA
Summary
InnateDB Gene IDBG-61242.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHKA
Gene Name choline kinase alpha
Synonyms CHK; CK; CKI; EK;
Species Homo sapiens
Ensembl Gene ENSG00000110721
Encoded Proteins
choline kinase alpha
choline kinase alpha
choline kinase alpha
choline kinase alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68052859-68121444
Strand Reverse strand
Band q13.2
Transcripts
ENST00000265689 ENSP00000265689
ENST00000356135 ENSP00000348454
ENST00000533728
ENST00000525155 ENSP00000432631
ENST00000533910
ENST00000528235
ENST00000531341 ENSP00000435032
ENST00000530730
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004103 choline kinase activity
GO:0004104 cholinesterase activity
GO:0004305 ethanolamine kinase activity
GO:0004871 signal transducer activity
GO:0005524 ATP binding
GO:0008144 drug binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0033265 choline binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006644 phospholipid metabolic process
GO:0006646 phosphatidylethanolamine biosynthetic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0006657 CDP-choline pathway
GO:0006869 lipid transport
GO:0007165 signal transduction
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0019695 choline metabolic process
GO:0044281 small molecule metabolic process
GO:0046474 glycerophospholipid biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Synthesis of PC pathway
Phospholipid metabolism pathway
Synthesis of PE pathway
Metabolism pathway
KEGG
Glycerophospholipid metabolism pathway
INOH
PID BIOCARTA
Phosphatidylcholine biosynthesis pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001277 NM_212469
HUGO
OMIM
CCDS CCDS8178 CCDS8179
HPRD 00327
IMGT
EMBL
GenPept
RNA Seq Atlas