InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CHKA

Summary

InnateDB Gene

IDBG-61242.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHKA

Gene Name

choline kinase alpha

Synonyms

CHK; CK; CKI; EK

Species

Homo sapiens

Ensembl Gene

ENSG00000110721

Encoded Proteins

IDBP-61244

choline kinase alpha

IDBP-61246

choline kinase alpha

IDBP-583176

choline kinase alpha

IDBP-591836

choline kinase alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:68052859-68121444

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000265689	ENSP00000265689
ENST00000356135	ENSP00000348454
ENST00000533728
ENST00000525155	ENSP00000432631
ENST00000533910
ENST00000528235
ENST00000531341	ENSP00000435032
ENST00000530730

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004103	choline kinase activity
GO:0004104	cholinesterase activity
GO:0004305	ethanolamine kinase activity
GO:0004871	signal transducer activity
GO:0005524	ATP binding
GO:0008144	drug binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0033265	choline binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006644	phospholipid metabolic process
GO:0006646	phosphatidylethanolamine biosynthetic process
GO:0006656	phosphatidylcholine biosynthetic process
GO:0006657	CDP-choline pathway
GO:0006869	lipid transport
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0016310	phosphorylation
GO:0019695	choline metabolic process
GO:0044281	small molecule metabolic process
GO:0046474	glycerophospholipid biosynthetic process

Cellular Component

GO:0005829

cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024843

View Gene Order

ENSBTAG00000010304

Not yet available

Pathways

NETPATH

REACTOME

REACT_121238

Synthesis of PC pathway

REACT_120919

Synthesis of PE pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00564

Glycerophospholipid metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

H0YD02

UniProt Splice Variant

Entrez Gene

1119

UniGene

RefSeq

NM_001277 NM_212469

HUGO

HGNC:1937

OMIM

118491

CCDS

CCDS8178 CCDS8179

HPRD

00327

IMGT

EMBL

AP002807 AP002992

GenPept

RNA Seq Atlas

1119