InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RNF34

Summary

InnateDB Gene

IDBG-61735.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF34

Gene Name

ring finger protein 34, E3 ubiquitin protein ligase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000170633

Encoded Proteins

IDBP-61737

ring finger protein 34

IDBP-245613

ring finger protein 34

IDBP-245615

ring finger protein 34

IDBP-595753

ring finger protein 34

IDBP-600540

ring finger protein 34

IDBP-593968

ring finger protein 34

IDBP-585594

ring finger protein 34

IDBP-810652

ring finger protein 34, E3 ubiquitin protein ligase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:121400041-121430623

Strand

Forward strand

Band

q24.31

Transcripts

ENST00000361234	ENSP00000355137
ENST00000392465	ENSP00000376258
ENST00000392464	ENSP00000376257
ENST00000556562
ENST00000553407
ENST00000554606	ENSP00000452096
ENST00000555076	ENSP00000452200
ENST00000554868	ENSP00000452321
ENST00000557402	ENSP00000451724
ENST00000554484
ENST00000613529	ENSP00000477987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016607	nuclear speck

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029474

View Gene Order

ENSBTAG00000002315

Not yet available

Pathways

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

G3V4D1 G3V504 G3V5F1

UniProt Splice Variant

Entrez Gene

80196

UniGene

Hs.292804 Hs.657765

RefSeq

NM_001256858 NM_025126 NM_194271

HUGO

HGNC:17297

OMIM

608299

CCDS

CCDS31915 CCDS73538 CCDS9221

HPRD

10509

IMGT

EMBL

AC048337 AC073650

GenPept

RNA Seq Atlas

80196