InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rnf34

Summary

InnateDB Gene

IDBG-198875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf34

Gene Name

ring finger protein 34

Synonyms

AW061037; AW536122; BC004042; C88279; RIFF

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029474

Encoded Proteins

IDBP-198877

ring finger protein 34

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170633:
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:122850188-122868945

Strand

Forward strand

Band

Transcripts

ENSMUST00000031434

ENSMUSP00000031434

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:1901981	phosphatidylinositol phosphate binding

Biological Process

GO:0016567	protein ubiquitination
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0012505	endomembrane system
GO:0016607	nuclear speck

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170633

View Gene Order

ENSBTAG00000002315

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q99KR6

TrEMBL

UniProt Splice Variant

Entrez Gene

80751

UniGene

Mm.388529 Mm.471993

RefSeq

NM_030564 XM_006530512

OMIM

CCDS

CCDS19656

HPRD

IMGT

MGI ID

MGI:2153340

MGI Symbol

Rnf34

EMBL

AF434815 AK045696 AK046274 AK046381 AK077221 AK132330 AK137606 AK150976 AK159753 BC004042

GenPept

AAH04042 AAL30770 BAC32461 BAC32666 BAC32697 BAC36693 BAE21109 BAE23428 BAE30005 BAE35344

RNA Seq Atlas

80751