Version 5.4
Homo sapiens Gene: PLCH1
Summary
InnateDB Gene IDBG-62240.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCH1
Gene Name phospholipase C, eta 1
Synonyms PLCL3
Species Homo sapiens
Ensembl Gene ENSG00000114805
Encoded Proteins
IDBP-62244
phospholipase C, eta 1
IDBP-62246
phospholipase C, eta 1
IDBP-384993
phospholipase C, eta 1
IDBP-475474
phospholipase C, eta 1
IDBP-478333
phospholipase C, eta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:155375580-155745067
Strand Reverse strand
Band q25.31
Transcripts
ENST00000340059 ENSP00000345988
ENST00000334686 ENSP00000335469
ENST00000447496 ENSP00000402759
ENST00000494598 ENSP00000419100
ENST00000460012 ENSP00000417502
ENST00000469040
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0050429 calcium-dependent phospholipase C activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036834
View Gene Order
ENSBTAG00000008307
Not yet available
Pathways
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567423
RefSeq NM_001130960 NM_001130961 NM_014996 XM_005247238 XM_005247239 XM_006713541
HUGO
OMIM
CCDS CCDS33881 CCDS46939 CCDS46940
HPRD 11438
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca