Version 5.4
Bos taurus Gene: PLCH1
Summary
InnateDB Gene IDBG-637434.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLCH1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008307
Encoded Proteins
IDBP-689448
phospholipase C, eta 1
IDBP-689450
phospholipase C, eta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114805:
PLCH1 is a member of the PLC-eta family of the phosphoinositide-specific phospholipase C (PLC) superfamily of enzymes that cleave phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to generate second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) (Hwang et al., 2005 [PubMed 15702972]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:112962334-113071514
Strand Forward strand
Band
Transcripts
ENSBTAT00000065611 ENSBTAP00000056439
ENSBTAT00000010937 ENSBTAP00000010937
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004871 signal transducer activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0050429 calcium-dependent phospholipase C activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0016042 lipid catabolic process
GO:0035556 intracellular signal transduction
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114805
View Gene Order
ENSMUSG00000036834
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
REACT_188937
Metabolism pathway
REACT_196476
Inositol phosphate metabolism pathway
REACT_196473
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MF11
UniProt Splice Variant
Entrez Gene 513565
UniGene
RefSeq
HUGO HGNC:29185
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02002548
GenPept
RNA Seq Atlas 513565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca