Homo sapiens Gene: CD83
Summary
InnateDB Gene IDBG-62750.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD83
Gene Name CD83 molecule
Synonyms BL11; HB15;
Species Homo sapiens
Ensembl Gene ENSG00000112149
Encoded Proteins
CD83 molecule
CD83 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a single-pass type I membrane protein and member of the immunoglobulin superfamily of receptors. The encoded protein may be involved in the regulation of antigen presentation. A soluble form of this protein can bind to dendritic cells and inhibit their maturation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:14117256-14136918
Strand Forward strand
Band p23
Transcripts
ENST00000379153 ENSP00000368450
ENST00000612003 ENSP00000480760
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 3 [view]
Protein-DNA 6 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0014070 response to organic cyclic compound
GO:0032713 negative regulation of interleukin-4 production
GO:0032733 positive regulation of interleukin-10 production
GO:0032743 positive regulation of interleukin-2 production
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001040280 NM_001251901 NM_004233
HUGO
OMIM
CCDS CCDS4532 CCDS75403
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas