InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.17940

Summary

InnateDB Gene

IDBG-628611.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.17940

Gene Name

renin precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021333

Encoded Proteins

IDBP-679989

Uncharacterized protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143839:
Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1752891-1762733

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000028438

ENSBTAP00000028438

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004175	endopeptidase activity
GO:0004190	aspartic-type endopeptidase activity
GO:0005102	receptor binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity

Biological Process

GO:0001822	kidney development
GO:0001823	mesonephros development
GO:0002003	angiotensin maturation
GO:0002016	regulation of blood volume by renin-angiotensin
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0006508	proteolysis
GO:0008584	male gonad development
GO:0009755	hormone-mediated signaling pathway
GO:0010033	response to organic substance
GO:0042756	drinking behavior
GO:0043408	regulation of MAPK cascade
GO:0048469	cell maturation