InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TAP1

Summary

InnateDB Gene

IDBG-628856.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAP1

Gene Name

antigen peptide transporter 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000008953

Encoded Proteins

IDBP-680237

antigen peptide transporter 1

IDBP-680241

antigen peptide transporter 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168394:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:7117863-7126822

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000048986	ENSBTAP00000045934
ENSBTAT00000011787	ENSBTAP00000011787

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015197	peptide transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0023029	MHC class Ib protein binding
GO:0042288	MHC class I protein binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0043531	ADP binding
GO:0046979	TAP2 binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006952	defense response
GO:0008152	metabolic process
GO:0015833	peptide transport
GO:0019060	intracellular transport of viral protein in host cell
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0046967	cytosol to ER transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0042825	TAP complex