InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tap1

Summary

InnateDB Gene

IDBG-170616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tap1

Gene Name

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Synonyms

ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1; PSF1; RING4; TAP; Tap-1; Y3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037321

Encoded Proteins

IDBP-170618

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

IDBP-627117

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

IDBP-627122

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34187553-34197225

Strand

Forward strand

Band

Transcripts

ENSMUST00000041633	ENSMUSP00000039264
ENSMUST00000170086	ENSMUSP00000128401
ENSMUST00000166287
ENSMUST00000166853
ENSMUST00000168351
ENSMUST00000171148	ENSMUSP00000130189
ENSMUST00000166582

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	6 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015197	peptide transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0023029	MHC class Ib protein binding
GO:0042288	MHC class I protein binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0043531	ADP binding
GO:0046979	TAP2 binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0006952	defense response
GO:0015833	peptide transport
GO:0019060	intracellular transport of viral protein in host cell
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0046967	cytosol to ER transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0030670	phagocytic vesicle membrane
GO:0042825	TAP complex