Mus musculus Gene: Tap1
Summary
InnateDB Gene IDBG-170616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tap1
Gene Name transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms ABC17; Abcb2; APT1; Ham-1; Ham1; MTP1; PSF1; RING4; TAP; Tap-1; Y3;
Species Mus musculus
Ensembl Gene ENSMUSG00000037321
Encoded Proteins
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This protein forms a heterodimer with Tap2 that transports short peptides from the cytosol into the endoplasmic reticulum lumen. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34187553-34197225
Strand Forward strand
Band B1
Transcripts
ENSMUST00000041633 ENSMUSP00000039264
ENSMUST00000170086 ENSMUSP00000128401
ENSMUST00000166287
ENSMUST00000166853
ENSMUST00000168351
ENSMUST00000171148 ENSMUSP00000130189
ENSMUST00000166582
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 6 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 31 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015197 peptide transporter activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0023029 MHC class Ib protein binding
GO:0042288 MHC class I protein binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043531 ADP binding
GO:0046979 TAP2 binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006952 defense response
GO:0015833 peptide transport
GO:0019060 intracellular transport of viral protein in host cell
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0046967 cytosol to ER transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0030670 phagocytic vesicle membrane
GO:0042825 TAP complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
KEGG
ABC transporters pathway
Phagosome pathway
Antigen processing and presentation pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
ABC transporters pathway
Phagosome pathway
Antigen processing and presentation pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
Antigen processing and presentation [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt P21958
TrEMBL Q3TBA3 Q9QWR3
UniProt Splice Variant
Entrez Gene 21354
UniGene Mm.482076
RefSeq NM_001161730 NM_013683
OMIM
CCDS CCDS28643 CCDS50072
HPRD
IMGT
MGI ID MGI:98483
MGI Symbol Tap1
EMBL AF027865 AK162731 AK171363 CH466660 CR974422 D14566 M55637 U60018 U60019 X59615
GenPept AAA39570 AAB41962 AAB41963 AAB81534 BAA22520 BAE37041 BAE42411 CAA42178 EDL10260
RNA Seq Atlas 21354