Bos taurus Gene: ITPR3
Summary
InnateDB Gene IDBG-629118.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPR3
Gene Name inositol 1,4,5-trisphosphate receptor type 3
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013245
Encoded Proteins
inositol 1,4,5-trisphosphate receptor type 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] ITPR3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.
[Mus musculus] Itpr3 facilitates depletion of intracellular Ca(2+) for the internalization phase of FcgR-mediated phagocytosis.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000096433:
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:7687261-7756803
Strand Forward strand
Band
Transcripts
ENSBTAT00000053490 ENSBTAP00000047648
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005218 intracellular ligand-gated calcium channel activity
GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262 calcium channel activity
GO:0005488 binding
GO:0005515 protein binding
GO:0035091 phosphatidylinositol binding
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007613 memory
GO:0050913 sensory perception of bitter taste
GO:0050916 sensory perception of sweet taste
GO:0050917 sensory perception of umami taste
GO:0051592 response to calcium ion
GO:0055085 transmembrane transport
GO:0060291 long-term synaptic potentiation
GO:0060402 calcium ion transport into cytosol
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DAG and IP3 signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
Elevation of cytosolic Ca2+ levels pathway
Platelet homeostasis pathway
Effects of PIP2 hydrolysis pathway
PLC-gamma1 signalling pathway
EGFR interacts with phospholipase C-gamma pathway
Signaling by EGFR pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
PLC beta mediated events pathway
Opioid Signalling pathway
PLCG1 events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
Phospholipase C-mediated cascade pathway
Signaling by FGFR pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
Regulation of insulin secretion pathway
Integration of energy metabolism pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Platelet calcium homeostasis pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G-protein mediated events pathway
Adaptive Immune System pathway
Immune System pathway
VEGFR2 mediated cell proliferation pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Metabolism pathway
FCERI mediated Ca+2 mobilization pathway
Signaling by the B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PLCG1 events in ERBB2 signaling pathway
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
GPCR downstream signaling pathway
Disease pathway
Platelet homeostasis pathway
Hemostasis pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Integration of energy metabolism pathway
Role of phospholipids in phagocytosis pathway
Signaling by VEGF pathway
Platelet calcium homeostasis pathway
Signaling by FGFR in disease pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
beta-catenin independent WNT signaling pathway
VEGFR2 mediated cell proliferation pathway
PLC-gamma1 signalling pathway
Metabolism pathway
Immune System pathway
Platelet activation, signaling and aggregation pathway
EGFR interacts with phospholipase C-gamma pathway
Regulation of insulin secretion pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Effects of PIP2 hydrolysis pathway
Signaling by EGFR pathway
Phospholipase C-mediated cascade pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
Ca2+ pathway pathway
FCERI mediated Ca+2 mobilization pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
DAG and IP3 signaling pathway
Elevation of cytosolic Ca2+ levels pathway
NGF signalling via TRKA from the plasma membrane pathway
G alpha (q) signalling events pathway
Opioid Signalling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion pathway
PLC beta mediated events pathway
G-protein mediated events pathway
Signaling by EGFR in Cancer pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
GnRH signaling pathway pathway
Gap junction pathway
Long-term potentiation pathway
Alzheimer's disease pathway
Phosphatidylinositol signaling system pathway
Taste transduction pathway
Long-term depression pathway
Calcium signaling pathway pathway
Vascular smooth muscle contraction pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Salivary secretion pathway
Taste transduction pathway
Calcium signaling pathway pathway
Alzheimer's disease pathway
Gap junction pathway
Phosphatidylinositol signaling system pathway
GnRH signaling pathway pathway
Long-term potentiation pathway
Long-term depression pathway
Vascular smooth muscle contraction pathway
Oocyte meiosis pathway
Gastric acid secretion pathway
Salivary secretion pathway
Pancreatic secretion pathway
INOH
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
CD4 T cell receptor signaling pathway
B cell receptor signaling pathway
VEGF signaling pathway pathway
GPCR GroupI metabotropic glutamate receptor signaling pathway pathway
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.9025
RefSeq NM_174370
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas