Bos taurus Gene: PPAP2A | |||||||
---|---|---|---|---|---|---|---|
Summary | |||||||
InnateDB Gene | IDBG-629135.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | PPAP2A | ||||||
Gene Name | lipid phosphate phosphohydrolase 1 | ||||||
Synonyms | |||||||
Species | Bos taurus | ||||||
Ensembl Gene | ENSBTAG00000010526 | ||||||
Encoded Proteins |
lipid phosphate phosphohydrolase 1
|
||||||
Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067113:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in synthesis of glycerolipids and in phospholipase D-mediated signal transduction. This enzyme is an integral membrane glycoprotein that plays a role in the hydrolysis and uptake of lipids from extracellular space. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
||||||
Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 20:23658802-23793336 | ||||||
Strand | Forward strand | ||||||
Band | |||||||
Transcripts |
|
||||||
Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
|
||||||
Gene Ontology | |||||||
Molecular Function |
|
||||||
Biological Process |
|
||||||
Cellular Component |
|
||||||
Orthologs | |||||||
Species
Homo sapiens
Mus musculus
|
Gene ID
Gene Order
|
||||||
Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Sphingolipid de novo biosynthesis pathway
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
Sphingolipid de novo biosynthesis pathway
Metabolism pathway
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
|
||||||
KEGG |
Sphingolipid metabolism pathway
Glycerophospholipid metabolism pathway
Ether lipid metabolism pathway
Glycerolipid metabolism pathway
Fc gamma R-mediated phagocytosis pathway
Fat digestion and absorption pathway
Glycerophospholipid metabolism pathway
Sphingolipid metabolism pathway
Ether lipid metabolism pathway
Glycerolipid metabolism pathway
Fc gamma R-mediated phagocytosis pathway
Fat digestion and absorption pathway
|
||||||
INOH | |||||||
PID NCI |
p73 transcription factor network
Fc-epsilon receptor I signaling in mast cells
|
||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | Q32KV9 | ||||||
UniProt Splice Variant | |||||||
Entrez Gene | 617172 | ||||||
UniGene | Bt.103208 | ||||||
RefSeq | NM_001080329 | ||||||
HUGO | |||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | BC109901 DAAA02050342 DAAA02050343 DAAA02050344 | ||||||
GenPept | AAI09902 | ||||||
RNA Seq Atlas | 617172 | ||||||