Bos taurus Gene: IL10
Summary
InnateDB Gene IDBG-629159.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL10
Gene Name interleukin-10 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000006685
Encoded Proteins
interleukin-10 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL10 expression is regulated in different immune cells has revealed some of the molecular mechanisms involved at the levels of signal transduction, epigenetics, transcription factor binding and gene activation.
[Homo sapiens] IL10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. It also plays a role in microRNA function, specifically its inhibitory effect on miR-155 expression in response to LPS.
[Homo sapiens] IL10 is a pleiotropic cytokine released in many tissues that mediates anti-inflammatory effects. IL10 also has an immunomodulatory role by stimulating NKG2D ligand expression on macrophages, thereby rendering them susceptible to natural killer (NK) cell elimination.
[Homo sapiens] IL10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. Blockade of Il10 receptor during acute murine cytomegalovirus (CMV) infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung. (Demonstrated in murine model)
[Homo sapiens] IL10 has opposing functions in anti-microbial responses in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections.
[Homo sapiens] IL10-mediated suppression of natural killer/dendritic cell crosstalk leads to prolonged mouse cytomegalovirus (MCMV) persistence due to poor priming of MCMV-specific T cells. (Demonstrated in mouse)
[Homo sapiens] IL10 induces MIR187 to limit the expression of pro-inflammatory cytokines.
[Homo sapiens] MIR145 directly targets HDAC11 to promote IL10 expression in TLR4-triggered macrophages.
[Homo sapiens] HIV-1 infection of macrophages modulates host responses to co-infection with Mycobacterium tuberculosis by attenuating IL10 responses thus contributing to the pathogenesis of tuberculosis in HIV-1??infected patients.
[Homo sapiens] Secreted CCNA2 (CCN1) promotes anti-inflammatory cytokine IL10 release from epithelial cells via integrin αVβ6-PKC, and this subsequently suppresses TNF, CXCL2 and neutrophil infiltration in the lungs.
[Homo sapiens] MIR29A inhibits IL10-induced cytokine release by targeting JAK-STAT3 in monocytes during sepsis.
[Mus musculus] Il10 contributes to antiviral innate immunity during acute infection by restricting activation-induced death in natural killer (NK) cells. Blockade of Il10 receptor during acute murine cytomegalovirus (CMV) infection markedly reduced the accumulation of cytotoxic NK cells in the spleen and lung.
[Mus musculus] Il10 has opposing functions in anti-microbial responses in its capacity to mediate protective immunity against some organisms but increase susceptibility to other infections.
[Mus musculus] Il10-mediated suppression of natural killer/dendritic cell crosstalk leads to prolonged mouse cytomegalovirus (MCMV) persistence due to poor priming of MCMV-specific T cells.
[Mus musculus] Retinoic acid treatment enhances Tlr2-dependent Il10 production from T cells and this, in turn, potentiates T regulatory cell generation without the need for activation of antigen presenting cells.
[Mus musculus] Intestinal macrophages that constitutively produce IL10, control excessive innate immune activation and prevent tissue damage after an acute bacterial infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136634:
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.[provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4402474-4406421
Strand Reverse strand
Band
Transcripts
ENSBTAT00000008793 ENSBTAP00000008793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
Biological Process
GO:0002237 response to molecule of bacterial origin
GO:0002740 negative regulation of cytokine secretion involved in immune response
GO:0002875 negative regulation of chronic inflammatory response to antigenic stimulus
GO:0002904 positive regulation of B cell apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0010468 regulation of gene expression
GO:0030886 negative regulation of myeloid dendritic cell activation
GO:0030889 negative regulation of B cell proliferation
GO:0032689 negative regulation of interferon-gamma production
GO:0032695 negative regulation of interleukin-12 production
GO:0032715 negative regulation of interleukin-6 production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032800 receptor biosynthetic process
GO:0042742 defense response to bacterium
GO:0044130 negative regulation of growth of symbiont in host
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050715 positive regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051384 response to glucocorticoid
GO:0060670 branching involved in labyrinthine layer morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Leishmaniasis pathway
Staphylococcus aureus infection pathway
Amoebiasis pathway
Malaria pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
Toxoplasmosis pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
T cell receptor signaling pathway pathway
Asthma pathway
Allograft rejection pathway
Systemic lupus erythematosus pathway
Autoimmune thyroid disease pathway
Intestinal immune network for IgA production pathway
Staphylococcus aureus infection pathway
Leishmaniasis pathway
Amoebiasis pathway
Malaria pathway
Toxoplasmosis pathway
Chagas disease (American trypanosomiasis) pathway
African trypanosomiasis pathway
INOH
JAK STAT pathway and regulation pathway
GPCR signaling pathway
IL-10 signaling pathway
JAK STAT pathway and regulation pathway
GPCR signaling pathway
IL-10 signaling pathway
PID NCI
AP-1 transcription factor network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL F1MCS4
UniProt Splice Variant
Entrez Gene 281246
UniGene
RefSeq NM_174088
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02041972
GenPept
RNA Seq Atlas 281246