Bos taurus Gene: AADAT
Summary
InnateDB Gene IDBG-629270.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AADAT
Gene Name kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Synonyms AADAT;
Species Bos taurus
Ensembl Gene ENSBTAG00000010326
Encoded Proteins
kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109576:
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:1792852-1816770
Strand Reverse strand
Band
Transcripts
ENSBTAT00000013637 ENSBTAP00000013637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006536 glutamate metabolic process
GO:0009058 biosynthetic process
GO:0070189 kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Tryptophan catabolism pathway
Metabolism of amino acids and derivatives pathway
Lysine catabolism pathway
Metabolism pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Tryptophan catabolism pathway
Lysine catabolism pathway
KEGG
Lysine biosynthesis pathway
Lysine degradation pathway
Tryptophan metabolism pathway
Lysine biosynthesis pathway
Lysine degradation pathway
Tryptophan metabolism pathway
INOH
Lysine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MKS7
UniProt Splice Variant
Entrez Gene 520638
UniGene Bt.11485
RefSeq NM_001015551 XM_002689448 XM_005209789 XM_598886
HUGO HGNC:17929
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02021763 DAAA02021764
GenPept
RNA Seq Atlas 508929 520638