Mus musculus Gene: Aadat
Summary
InnateDB Gene IDBG-156441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aadat
Gene Name aminoadipate aminotransferase
Synonyms Aadt; AI875679; Kat2; KATII; mKat-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000057228
Encoded Proteins
aminoadipate aminotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109576:
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:60506124-60545677
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000079472 ENSMUSP00000078436
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006536 glutamate metabolic process
GO:0009058 biosynthetic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0070189 kynurenine metabolic process
GO:0097052 L-kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Tryptophan catabolism pathway
Lysine catabolism pathway
KEGG
Lysine biosynthesis pathway
Lysine degradation pathway
Tryptophan metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Tryptophan catabolism pathway
Metabolism of amino acids and derivatives pathway
Lysine catabolism pathway
Metabolism pathway
KEGG
Lysine biosynthesis pathway
Lysine degradation pathway
Tryptophan metabolism pathway
INOH
Lysine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9WVM8
TrEMBL
UniProt Splice Variant
Entrez Gene 23923
UniGene Mm.35020
RefSeq NM_011834
OMIM
CCDS CCDS22320
HPRD
IMGT
MGI ID MGI:1345167
MGI Symbol Aadat
EMBL AF072376 AK075578 BC012637
GenPept AAD39680 AAH12637 BAC35833
RNA Seq Atlas 23923