|Bos taurus Gene: IBTK
|2014-10-13 [Report errors or provide feedback]
|inhibitor of Bruton tyrosine kinase
inhibitor of Bruton agammaglobulinemia tyrosine kinase
|Stemformatics EHFPI ImmGen
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005700:
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. [provided by RefSeq, Jul 2008]
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK\'s kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
|Number of Interactions
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data
BCR signaling pathway
|UniProt Splice Variant
|NM_001206040 XM_005210695 XM_005210696
|RNA Seq Atlas