Version 5.4
Bos taurus Gene: REV1
Summary
InnateDB Gene IDBG-630283.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REV1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000043999
Encoded Proteins
IDBP-681824
REV1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135945:
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:4502869-4599212
Strand Reverse strand
Band
Transcripts
ENSBTAT00000061518 ENSBTAP00000053649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0017125 deoxycytidyl transferase activity
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0009411 response to UV
GO:0042276 error-prone translesion synthesis
Cellular Component
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135945
View Gene Order
ENSMUSG00000026082
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8
Translesion synthesis by HREV1 pathway
REACT_2198
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
REACT_2174
DNA Damage Bypass pathway
REACT_216
DNA Repair pathway
REACT_216200
Translesion synthesis by HREV1 pathway
REACT_233397
DNA Repair pathway
REACT_218307
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
REACT_226050
DNA Damage Bypass pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1N787
UniProt Splice Variant
Entrez Gene 616986
UniGene
RefSeq XM_003586611 XM_591379
HUGO HGNC:14060
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02030163 DAAA02030164 DAAA02030165 DAAA02030166 DAAA02030167 DAAA02030168
GenPept
RNA Seq Atlas 513657 616986
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca