Mus musculus Gene: Rev1
Summary
InnateDB Gene IDBG-146762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rev1
Gene Name REV1 homolog (S. cerevisiae)
Synonyms 1110027I23Rik; AU022044; Rev1l;
Species Mus musculus
Ensembl Gene ENSMUSG00000026082
Encoded Proteins
REV1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135945:
This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. Two alternatively spliced transcript variants that encode different proteins have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:38052787-38129662
Strand Reverse strand
Band B
Transcripts
ENSMUST00000027251 ENSMUSP00000027251
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0017125 deoxycytidyl transferase activity
Biological Process
GO:0006261 DNA-dependent DNA replication
GO:0006281 DNA repair
GO:0009411 response to UV
GO:0042276 error-prone translesion synthesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Translesion synthesis by HREV1 pathway
DNA Repair pathway
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
DNA Damage Bypass pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Translesion synthesis by DNA polymerases bypassing lesion on DNA template pathway
Translesion synthesis by HREV1 pathway
DNA Damage Bypass pathway
DNA Repair pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q920Q2
TrEMBL Q3V4D4
UniProt Splice Variant
Entrez Gene 56210
UniGene Mm.389103 Mm.454676
RefSeq NM_019570 XM_006496153 XM_006496154 XM_006496156 XM_006496158 XM_006496159 XM_006496160 XM_006496163 XM_006496165
OMIM
CCDS CCDS14899
HPRD
IMGT
MGI ID MGI:1929074
MGI Symbol Rev1
EMBL AB057418 AF179302 AK003934 BC058093
GenPept AAF23323 AAH58093 BAB64933 BAE43152
RNA Seq Atlas 56210