Bos taurus Gene: VCL
Summary
InnateDB Gene IDBG-630608.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VCL
Gene Name vinculin
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021879
Encoded Proteins
Uncharacterized protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000035403:
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 28:30053806-30166317
Strand Forward strand
Band
Transcripts
ENSBTAT00000061210 ENSBTAP00000053644
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 136 interaction(s) predicted by orthology.
Predicted by orthology
Total 136 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002162 dystroglycan binding
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0045294 alpha-catenin binding
GO:0051015 actin filament binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0007155 cell adhesion
GO:0030032 lamellipodium assembly
GO:0030334 regulation of cell migration
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0043297 apical junction assembly
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0043034 costamere
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
IL3 pathway
REACTOME
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Smooth Muscle Contraction pathway
Platelet activation, signaling and aggregation pathway
Muscle contraction pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Smooth Muscle Contraction pathway
Platelet activation, signaling and aggregation pathway
Muscle contraction pathway
Response to elevated platelet cytosolic Ca2+ pathway
KEGG
Regulation of actin cytoskeleton pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Regulation of actin cytoskeleton pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
Focal adhesion pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
INOH
Integrin signaling pathway pathway
Integrin signaling pathway pathway
PID NCI
Integrins in angiogenesis
Signaling events mediated by focal adhesion kinase
Signaling events mediated by VEGFR1 and VEGFR2
RhoA signaling pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL F1N789 Q0VCE6 Q2PQT6
UniProt Splice Variant
Entrez Gene 783645
UniGene Bt.111207 Bt.37667
RefSeq NM_001191370 XM_005226481
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120206 DAAA02061908 DQ306921
GenPept AAI20207 ABC25001
RNA Seq Atlas 783645