InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VCL

Summary

InnateDB Gene

IDBG-78928.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCL

Gene Name

vinculin

Synonyms

CMD1W; CMH15; HEL114; MV; MVCL

Species

Homo sapiens

Ensembl Gene

ENSG00000035403

Encoded Proteins

IDBP-78930

vinculin

IDBP-78932

vinculin

IDBP-380384

vinculin

IDBP-811517

vinculin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:73995193-74121363

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000372755	ENSP00000361841
ENST00000211998	ENSP00000211998
ENST00000436396	ENSP00000415489
ENST00000478896
ENST00000461383
ENST00000472585
ENST00000623461
ENST00000624354	ENSP00000485551

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	213 [view]
Protein-Protein	212 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding
GO:0051015	actin filament binding

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0002576	platelet degranulation
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007596	blood coagulation
GO:0030032	lamellipodium assembly
GO:0030168	platelet activation
GO:0030334	regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0034333	adherens junction assembly
GO:0034394	protein localization to cell surface
GO:0043297	apical junction assembly
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030055	cell-substrate junction
GO:0043034	costamere
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome