Homo sapiens Gene: VCL
Summary
InnateDB Gene IDBG-78928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VCL
Gene Name vinculin
Synonyms CMD1W; CMH15; HEL114; MV; MVCL;
Species Homo sapiens
Ensembl Gene ENSG00000035403
Encoded Proteins
vinculin
vinculin
vinculin
vinculin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:73995193-74121363
Strand Forward strand
Band q22.2
Transcripts
ENST00000372755 ENSP00000361841
ENST00000211998 ENSP00000211998
ENST00000436396 ENSP00000415489
ENST00000478896
ENST00000461383
ENST00000472585
ENST00000623461
ENST00000624354 ENSP00000485551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 213 [view]
Protein-Protein 212 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002162 dystroglycan binding
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0002576 platelet degranulation
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0030334 regulation of cell migration
GO:0030336 negative regulation of cell migration
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0043297 apical junction assembly
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005916 fascia adherens
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030055 cell-substrate junction
GO:0043034 costamere
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
IL3 pathway
REACTOME
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Smooth Muscle Contraction pathway
Response to elevated platelet cytosolic Ca2+ pathway
Muscle contraction pathway
Hemostasis pathway
KEGG
Focal adhesion pathway
Adherens junction pathway
Leukocyte transendothelial migration pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Shigellosis pathway
Amoebiasis pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Cell to cell adhesion signaling [Biocarta view]
Integrin signaling pathway [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
PID NCI
Integrins in angiogenesis
Signaling events mediated by focal adhesion kinase
Signaling events mediated by VEGFR1 and VEGFR2
RhoA signaling pathway
Stabilization and expansion of the E-cadherin adherens junction
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.605794 Hs.643896
RefSeq NM_003373 NM_014000 XM_005270142 XM_005270143
HUGO
OMIM
CCDS CCDS7340 CCDS7341
HPRD 01900
IMGT
EMBL
GenPept
RNA Seq Atlas