InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IL1R1

Summary

InnateDB Gene

IDBG-630765.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL1R1

Gene Name

interleukin-1 receptor type 1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000005273

Encoded Proteins

IDBP-682303

interleukin 1 receptor, type I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18996842

[Homo sapiens] IL1R1 is a substrate for presenilin-dependent gamma-secretase cleavage and intramembrane proteolysis may be a control mechanism for IL1R1-mediated signalling.

PMID 21115691

[Homo sapiens] IL1R1 is essential for TLR9-dependent activation of tumour necrosis factor receptor-associated factor 3 (TRAF3) and for production of the anti-inflammatory cytokines IL-10 and type I interferon (IFN).

PMID 22426547

[Homo sapiens] IL1R1 is the primary receptor for the inflammatory cytokine IL1B.

PMID 22426547

[Mus musculus] Il1r1 is the primary receptor for the inflammatory cytokine Il1b. (Demonstrated in human)

PMID 23440414

[Mus musculus] IL1R1 upregulates Mir135b as a negative feedback regulatory mechanism to resolve cigarette smoke-induced inflammation in the lung.

PMID 24651866

[Mus musculus] In response to adenovirus infection, the IL1A-IL1R1-CXCR2 signalling axis cooperates with complement to recruit Ly-6G+7/4+ polymorphonuclear leukocytes to the splenic marginal zone (MZ) in the proximity of virus-containing MARCO+ residential MZ macrophages, which are subsequently eliminated.

PMID 25461404

[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115594:
The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is a receptor for interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. [provided by RefSeq, Jul 2008]
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:6876948-6929909

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006938

ENSBTAP00000006938

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004871	signal transducer activity
GO:0004908	interleukin-1 receptor activity
GO:0004909	interleukin-1, Type I, activating receptor activity
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0019221	cytokine-mediated signaling pathway
GO:0050727	regulation of inflammatory response
GO:0070555	response to interleukin-1