InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SEMA3E

Summary

InnateDB Gene

IDBG-631012.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA3E

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000014920

Encoded Proteins

IDBP-682556

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170381:
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:37294908-37417444

Strand

Forward strand

Band

Transcripts

ENSBTAT00000019866

ENSBTAP00000019866

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030215	semaphorin receptor binding

Biological Process

GO:0001569	patterning of blood vessels
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0007275	multicellular organismal development
GO:0008360	regulation of cell shape
GO:0016525	negative regulation of angiogenesis
GO:0050808	synapse organization
GO:0071526	semaphorin-plexin signaling pathway
GO:2000249	regulation of actin cytoskeleton reorganization