Bos taurus Gene: PARP1
Summary
InnateDB Gene IDBG-631108.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP1
Gene Name poly
Synonyms ADPRT; ARTD1;
Species Bos taurus
Ensembl Gene ENSBTAG00000000837
Encoded Proteins
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143799:
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30119202-30160574
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001113 ENSBTAP00000001113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 182 interaction(s) predicted by orthology.
Predicted by orthology
Total 182 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
GO:0047485 protein N-terminus binding
GO:0051287 NAD binding
Biological Process
GO:0000723 telomere maintenance
GO:0006259 DNA metabolic process
GO:0006284 base-excision repair
GO:0006302 double-strand break repair
GO:0006471 protein ADP-ribosylation
GO:0032869 cellular response to insulin stimulus
GO:0040009 regulation of growth rate
GO:0070212 protein poly-ADP-ribosylation
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
AndrogenReceptor pathway
TWEAK pathway
Oncostatin_M pathway
REACTOME
SMAD4 MH2 Domain Mutants in Cancer pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
Generic Transcription Pathway pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Gene Expression pathway
Disease pathway
Signaling by TGF-beta Receptor Complex pathway
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
KEGG
Base excision repair pathway
Base excision repair pathway
INOH
PID BIOCARTA
Opposing roles of aif in apoptosis and cell survival [Biocarta view]
Induction of apoptosis through dr3 and dr4/5 death receptors [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL F1MU08
UniProt Splice Variant
Entrez Gene 286764
UniGene Bt.4803
RefSeq NM_174751 XM_005216796
HUGO HGNC:270
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02042671
GenPept
RNA Seq Atlas 286764
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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