Bos taurus Gene: SAP18
Summary
InnateDB Gene IDBG-631159.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAP18
Gene Name Histone deacetylase complex subunit SAP18
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018631
Encoded Proteins
Histone deacetylase complex subunit SAP18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000150459:
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:35860636-35868470
Strand Reverse strand
Band
Transcripts
ENSBTAT00000024791 ENSBTAP00000024791
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.
Predicted by orthology
Total 100 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000381 regulation of alternative mRNA splicing, via spliceosome
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043065 positive regulation of apoptotic process
GO:0048025 negative regulation of mRNA splicing, via spliceosome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
GO:0035145 exon-exon junction complex
GO:0061574 ASAP complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Epigenetic regulation of gene expression pathway
Gene Expression pathway
Chromatin organization pathway
HDACs deacetylate histones pathway
NoRC negatively regulates rRNA expression pathway
Negative epigenetic regulation of rRNA expression pathway
Chromatin modifying enzymes pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Hedgehog pathway
REACTOME
Epigenetic regulation of gene expression pathway
NoRC negatively regulates rRNA expression pathway
HDACs deacetylate histones pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Gene Expression pathway
Negative epigenetic regulation of rRNA expression pathway
Mus musculus biological processes pathway
NoRC negatively regulates rRNA expression pathway
Chromatin organization pathway
NoRC negatively regulates rRNA expression pathway
Chromatin modifying enzymes pathway
Epigenetic regulation of gene expression pathway
Gene Expression pathway
Negative epigenetic regulation of rRNA expression pathway
HDACs deacetylate histones pathway
KEGG
RNA transport pathway
mRNA surveillance pathway pathway
RNA transport pathway
mRNA surveillance pathway pathway
INOH
PID BIOCARTA
Mechanisms of transcriptional repression by dna methylation [Biocarta view]
PID NCI
Signaling events mediated by HDAC Class I
Regulation of nuclear SMAD2/3 signaling
Hedgehog signaling events mediated by Gli proteins
Regulation of Telomerase
Cross-References
SwissProt Q3T022
TrEMBL G3X7E1
UniProt Splice Variant
Entrez Gene 615692
UniGene Bt.48904 Bt.96610
RefSeq NM_001035467
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102603 DAAA02033233
GenPept AAI02604
RNA Seq Atlas 615692
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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