Bos taurus Gene: SCN4B
InnateDB Gene IDBG-631226.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCN4B
Gene Name Sodium channel subunit beta-4
Species Bos taurus
Ensembl Gene ENSBTAG00000039340
Encoded Proteins
Sodium channel subunit beta-4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177098:
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:29257448-29277309
Strand Reverse strand
ENSBTAT00000017826 ENSBTAP00000017826
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0017080 sodium channel regulator activity
GO:0044325 ion channel binding
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0010765 positive regulation of sodium ion transport
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0060048 cardiac muscle contraction
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086012 membrane depolarization during cardiac muscle cell action potential
GO:0086067 AV node cell to bundle of His cell communication
GO:0086091 regulation of heart rate by cardiac conduction
GO:2000649 regulation of sodium ion transmembrane transporter activity
Cellular Component
GO:0001518 voltage-gated sodium channel complex
GO:0005886 plasma membrane
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031226 intrinsic component of plasma membrane
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
Interaction between L1 and Ankyrins pathway
L1CAM interactions pathway
Developmental Biology pathway
Axon guidance pathway
SwissProt Q08E08
UniProt Splice Variant
Entrez Gene 538100
UniGene Bt.34480
RefSeq NM_001076912
EMBL BC123479 GJ062397
GenPept AAI23480 DAA22388
RNA Seq Atlas 538100
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)