InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SCN4B

Summary

InnateDB Gene

IDBG-631226.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN4B

Gene Name

Sodium channel subunit beta-4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000039340

Encoded Proteins

IDBP-682737

Sodium channel subunit beta-4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000177098:
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:29257448-29277309

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017826

ENSBTAP00000017826

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006810	transport
GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0010765	positive regulation of sodium ion transport
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086067	AV node cell to bundle of His cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000177098

View Gene Order

ENSMUSG00000046480

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q08E08

TrEMBL

V6F7R8

UniProt Splice Variant

Entrez Gene

538100

UniGene

Bt.34480

RefSeq

NM_001076912

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC123479 GJ062397

GenPept

AAI23480 DAA22388

RNA Seq Atlas

538100

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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