InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCN4B

Summary

InnateDB Gene

IDBG-73460.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN4B

Gene Name

sodium channel, voltage-gated, type IV, beta subunit

Synonyms

ATFB17; LQT10; Navbeta4

Species

Homo sapiens

Ensembl Gene

ENSG00000177098

Encoded Proteins

IDBP-73462

sodium channel, voltage-gated, type IV, beta

IDBP-594043

sodium channel, voltage-gated, type IV, beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and one non-coding transcript variant have been found for this gene.[provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:118133377-118152888

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000324727	ENSP00000322460
ENST00000423160
ENST00000415030
ENST00000531550
ENST00000529878	ENSP00000436343
ENST00000532138

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding
GO:0017080	sodium channel regulator activity
GO:0044325	ion channel binding
GO:0086006	voltage-gated sodium channel activity involved in cardiac muscle cell action potential

Biological Process

GO:0006814	sodium ion transport
GO:0010765	positive regulation of sodium ion transport
GO:0035725	sodium ion transmembrane transport
GO:0060048	cardiac muscle contraction
GO:0060307	regulation of ventricular cardiac muscle cell membrane repolarization
GO:0086002	cardiac muscle cell action potential involved in contraction
GO:0086012	membrane depolarization during cardiac muscle cell action potential
GO:0086067	AV node cell to bundle of His cell communication
GO:0086091	regulation of heart rate by cardiac conduction
GO:2000649	regulation of sodium ion transmembrane transporter activity

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0031226	intrinsic component of plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000046480

View Gene Order

ENSBTAG00000039340

Not yet available

Pathways

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.65239

RefSeq

NM_001142348 NM_001142349 NM_174934

HUGO

OMIM

CCDS

CCDS44744 CCDS8389

HPRD

09749

IMGT

EMBL

GenPept

RNA Seq Atlas