InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CYLD

Summary

InnateDB Gene

IDBG-631654.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYLD

Gene Name

Ubiquitin carboxyl-terminal hydrolase CYLD

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006291

Encoded Proteins

IDBP-683214

Ubiquitin carboxyl-terminal hydrolase CYLD

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18636086

[Homo sapiens] CYLD is a negative regulator of DDX58(RIG-I)-mediated antiviral response by removing Lys 63-linked polyubiquitin chains from RIG-I and TBK1.

PMID 18643924

[Homo sapiens] CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia.

PMID 21119682

[Homo sapiens] CYLD is a deubiquitinase that counteracts E3 ligases and therefore play a prominent role in the downregulation of NF-κB signalling and homeostasis.

PMID 21498625

[Homo sapiens] CYLD is a deubiquitinase that act as a negative regulator of TLR3 induction in response to LPS.

PMID 21946435

[Homo sapiens] CYLD plays a key role in Type I IFN receptor signalling during vesicular stomatitis virus (VSV) infection. In the absence of CYLD, IFN-beta is ineffective in the induction of antiviral genes. (Demonstrated in mice)

PMID 22057290

[Homo sapiens] The E3 ligase ITCH and deubiquitinase CYLD act together to regulate TAK1 and inflammation.

PMID 25909817

[Homo sapiens] MIR362 promotes natural killer-cell function by the down-regulation of CYLD.

PMID 21498625

[Mus musculus] Cyld is a deubiquitinase that act as a negative regulator of TLR3 induction in response to LPS. (Demonstrated in human)

PMID 21946435

[Mus musculus] Cyld plays a key role in Type I IFN receptor signalling during vesicular stomatitis virus (VSV) infection. In the absence of Cyld, IFN-beta is ineffective in the induction of antiviral genes.

PMID 22057290

[Mus musculus] The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083799:
This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:19224240-19293983

Strand

Forward strand

Band

Transcripts

ENSBTAT00000008257

ENSBTAP00000008257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0019901	protein kinase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0046872	metal ion binding
GO:0061578	Lys63-specific deubiquitinase activity
GO:0070064	proline-rich region binding

Biological Process

GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007346	regulation of mitotic cell cycle
GO:0016055	Wnt signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0070266	necroptotic process
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0070536	protein K63-linked deubiquitination
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005874	microtubule
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm