InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYLD

Summary

InnateDB Gene

IDBG-30697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYLD

Gene Name

cylindromatosis (turban tumor syndrome)

Synonyms

BRSS; CDMT; CYLD1; CYLDI; EAC; MFT; MFT1; SBS; TEM; USPL2

Species

Homo sapiens

Ensembl Gene

ENSG00000083799

Encoded Proteins

IDBP-30699

cylindromatosis (turban tumor syndrome)

IDBP-232729

cylindromatosis (turban tumor syndrome)

IDBP-376885

cylindromatosis (turban tumor syndrome)

IDBP-754543

IDBP-752445

IDBP-752609

IDBP-753875

IDBP-751306

IDBP-749823

IDBP-749016

IDBP-754305

IDBP-750151

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18636086

CYLD is a negative regulator of DDX58(RIG-I)-mediated antiviral response by removing Lys 63-linked polyubiquitin chains from RIG-I and TBK1.

PMID 18643924

CYLD is a crucial negative regulator of innate immune response in Escherichia coli pneumonia.

PMID 21119682

CYLD is a deubiquitinase that counteracts E3 ligases and therefore play a prominent role in the downregulation of NF-κB signalling and homeostasis.

PMID 21498625

CYLD is a deubiquitinase that act as a negative regulator of TLR3 induction in response to LPS.

PMID 21946435

CYLD plays a key role in Type I IFN receptor signalling during vesicular stomatitis virus (VSV) infection. In the absence of CYLD, IFN-beta is ineffective in the induction of antiviral genes. (Demonstrated in mice)

PMID 22057290

The E3 ligase ITCH and deubiquitinase CYLD act together to regulate TAK1 and inflammation.

PMID 25909817

MIR362 promotes natural killer-cell function by the down-regulation of CYLD.

InnateDB Annotation from Orthologs

Summary

PMID 21498625

[Mus musculus] Cyld is a deubiquitinase that act as a negative regulator of TLR3 induction in response to LPS. (Demonstrated in human)

PMID 21946435

[Mus musculus] Cyld plays a key role in Type I IFN receptor signalling during vesicular stomatitis virus (VSV) infection. In the absence of Cyld, IFN-beta is ineffective in the induction of antiviral genes.

PMID 22057290

[Mus musculus] The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation.

Entrez Gene

Summary

This gene is encodes a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains that functions as a deubiquitinating enzyme. Mutations in this gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:50742050-50801935

Strand

Forward strand

Band

q12.1

Transcripts

ENST00000311559	ENSP00000308928
ENST00000398568	ENSP00000381574
ENST00000427738	ENSP00000392025
ENST00000563629
ENST00000568704	ENSP00000456488
ENST00000569418	ENSP00000457576
ENST00000563976
ENST00000566024	ENSP00000458507
ENST00000564634	ENSP00000455535
ENST00000568744
ENST00000569891
ENST00000566679	ENSP00000456912
ENST00000564326	ENSP00000454515
ENST00000569681	ENSP00000457108
ENST00000566206	ENSP00000462134
ENST00000562884	ENSP00000463197

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	70 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019901	protein kinase binding
GO:0036459	ubiquitinyl hydrolase activity
GO:0061578	Lys63-specific deubiquitinase activity
GO:0070064	proline-rich region binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007346	regulation of mitotic cell cycle
GO:0016055	Wnt signaling pathway
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032480	negative regulation of type I interferon production
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0045087	innate immune response (InnateDB)
GO:0070266	necroptotic process
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070507	regulation of microtubule cytoskeleton organization
GO:0070536	protein K63-linked deubiquitination
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001242	regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005881	cytoplasmic microtubule
GO:0030496	midbody
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0048471	perinuclear region of cytoplasm