Version 5.4
| Bos taurus Gene: ZO2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-631855.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | ZO2 | ||||||||
| Gene Name | tight junction protein ZO-2 | ||||||||
| Synonyms | zo2 | ||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000011770 | ||||||||
| Encoded Proteins |
tight junction protein 2
tight junction protein 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119139:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 8:45598159-45696886 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
EGFR1 pathway
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| REACTOME |
Signaling by Hippo pathway
Apoptotic cleavage of cell adhesion proteins pathway
Apoptotic cleavage of cellular proteins pathway
Apoptotic execution phase pathway
Apoptosis pathway
Signal Transduction pathway
Signaling by Hippo pathway
Signal Transduction pathway
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| KEGG |
Vibrio cholerae infection pathway
Tight junction pathway
Tight junction pathway
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| INOH | |||||||||
| PID NCI |
Validated targets of C-MYC transcriptional repression
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | F1MBN2 Q95M46 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 407101 | ||||||||
| UniGene | Bt.109051 Bt.111745 Bt.29711 | ||||||||
| RefSeq | XM_005210006 XM_005210007 XM_005210008 XM_005210009 NM_001102482 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AJ313184 DAAA02022809 | ||||||||
| GenPept | CAC41970 | ||||||||
| RNA Seq Atlas | 407101 | ||||||||