Bos taurus Gene: ZO2
Summary
InnateDB Gene IDBG-631855.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZO2
Gene Name tight junction protein ZO-2
Synonyms zo2;
Species Bos taurus
Ensembl Gene ENSBTAG00000011770
Encoded Proteins
tight junction protein 2
tight junction protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119139:
This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:45598159-45696886
Strand Forward strand
Band
Transcripts
ENSBTAT00000047115 ENSBTAP00000044345
ENSBTAT00000015635 ENSBTAP00000015635
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Apoptotic execution phase pathway
Signaling by Hippo pathway
Apoptosis pathway
Signal Transduction pathway
Apoptotic cleavage of cell adhesion proteins pathway
Apoptotic cleavage of cellular proteins pathway
Signaling by Hippo pathway
Signal Transduction pathway
KEGG
Tight junction pathway
Vibrio cholerae infection pathway
Tight junction pathway
INOH
PID BIOCARTA
PID NCI
Validated targets of C-MYC transcriptional repression
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.109051 Bt.111745 Bt.29711
RefSeq NM_001102482 XM_005210006 XM_005210007 XM_005210008 XM_005210009
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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