InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: TGFA

Summary

InnateDB Gene

IDBG-631869.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TGFA

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000783

Encoded Proteins

IDBP-683435

transforming growth factor, alpha

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163235:
This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:13969792-13984394

Strand

Forward strand

Band

Transcripts

ENSBTAT00000001037

ENSBTAP00000001037

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0004708	MAP kinase kinase activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0000165	MAPK cascade
GO:0000187	activation of MAPK activity
GO:0001525	angiogenesis
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0050679	positive regulation of epithelial cell proliferation
GO:0060749	mammary gland alveolus development

Cellular Component

GO:0005615	extracellular space
GO:0009986	cell surface
GO:0016323	basolateral plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0048471	perinuclear region of cytoplasm