Version 5.4
Homo sapiens Gene: TGFA
Summary
InnateDB Gene IDBG-55377.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFA
Gene Name transforming growth factor, alpha
Synonyms TFGA
Species Homo sapiens
Ensembl Gene ENSG00000163235
Encoded Proteins
IDBP-55379
transforming growth factor, alpha
IDBP-241992
transforming growth factor, alpha
IDBP-378651
transforming growth factor, alpha
IDBP-378654
transforming growth factor, alpha
IDBP-378655
transforming growth factor, alpha
IDBP-378656
transforming growth factor, alpha
IDBP-378660
transforming growth factor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:70447280-70554193
Strand Reverse strand
Band p13.3
Transcripts
ENST00000295400 ENSP00000295400
ENST00000394241 ENSP00000377787
ENST00000418333 ENSP00000404099
ENST00000445399 ENSP00000387493
ENST00000419940 ENSP00000407432
ENST00000450929 ENSP00000414127
ENST00000444975 ENSP00000404131
ENST00000460808
ENST00000474101
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0004708 MAP kinase kinase activity
GO:0005154 epidermal growth factor receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0001525 angiogenesis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0042060 wound healing
GO:0042493 response to drug
GO:0043066 negative regulation of apoptotic process
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0045840 positive regulation of mitosis
GO:0048523 negative regulation of cellular process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051781 positive regulation of cell division
GO:0060749 mammary gland alveolus development
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029999
View Gene Order
ENSBTAG00000000783
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04012
ErbB signaling pathway pathway
hsa05211
Renal cell carcinoma pathway
hsa05214
Glioma pathway
hsa05215
Prostate cancer pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
GPCR signaling pathway
PID NCI
p53downstreampathway
Direct p53 effectors
erbb_network_pathway
ErbB receptor signaling network
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL F8VNR3 Q6QBS1 Q9UIS3 Q9UQ91
UniProt Splice Variant
Entrez Gene 7039
UniGene Hs.170009 Hs.606789 Hs.628298
RefSeq NM_001099691 NM_003236 XM_005264522
HUGO HGNC:11765
OMIM 190170
CCDS CCDS1905 CCDS46316
HPRD 07522
IMGT
EMBL AC005234 AC017084 AF075585 AF075586 AF149099 AF149100 AY548763
GenPept AAD12239 AAF06730 AAS83396
RNA Seq Atlas 7039

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca