Version 5.4
Bos taurus Gene: HSPA8
Summary
InnateDB Gene IDBG-632251.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPA8
Gene Name Heat shock cognate 71 kDa protein
Synonyms Hsc70; HSPA10
Species Bos taurus
Ensembl Gene ENSBTAG00000013162
Encoded Proteins
IDBP-683858
Heat shock cognate 71 kDa protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109971:
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:34216278-34220705
Strand Reverse strand
Band
Transcripts
ENSBTAT00000017497 ENSBTAP00000017497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 257 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 257 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0019899 enzyme binding
GO:0023026 MHC class II protein complex binding
GO:0031072 heat shock protein binding
GO:0042623 ATPase activity, coupled
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000902 cell morphogenesis
GO:0006200 ATP catabolic process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0006457 protein folding
GO:0006950 response to stress
GO:0008380 RNA splicing
GO:0042026 protein refolding
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051726 regulation of cell cycle
GO:0072318 clathrin coat disassembly
GO:1902904 negative regulation of fibril organization
Cellular Component
GO:0000974 Prp19 complex
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000109971
View Gene Order
ENSMUSG00000015656
View Gene Order
Pathways
NETPATH
REACTOME
REACT_218726
Regulation of HSF1-mediated heat shock response pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_205580
HSF1-dependent transactivation pathway
REACT_206725
mRNA Splicing pathway
REACT_226413
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_215526
L1CAM interactions pathway
REACT_206069
Cellular responses to stress pathway
REACT_226022
Gene Expression pathway
REACT_227515
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_203140
Axon guidance pathway
REACT_225257
Cellular response to heat stress pathway
REACT_214880
CHL1 interactions pathway
REACT_213591
Attenuation phase pathway
REACT_220844
Developmental Biology pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_21
RANKL pathway
NetPath_23
TSH pathway
REACTOME
REACT_25325
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_23947
GABA synthesis, release, reuptake and degradation pathway
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_22292
CHL1 interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_13685
Neuronal System pathway
REACT_200624
Attenuation phase pathway
REACT_18266
Axon guidance pathway
REACT_200775
HSF1-dependent transactivation pathway
REACT_200819
Cellular response to heat stress pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_13723
Neurotransmitter Release Cycle pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_1735
mRNA Splicing pathway
REACT_71
Gene Expression pathway
REACT_11123
Membrane Trafficking pathway
REACT_249110
mRNA Splicing pathway
REACT_209837
Membrane Trafficking pathway
REACT_245631
GABA synthesis, release, reuptake and degradation pathway
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_188957
Cellular responses to stress pathway
REACT_198693
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_231722
Lysosome Vesicle Biogenesis pathway
REACT_232671
Golgi Associated Vesicle Biogenesis pathway
REACT_213550
HSF1-dependent transactivation pathway
REACT_224790
Cellular response to heat stress pathway
REACT_250087
Neurotransmitter Release Cycle pathway
REACT_223784
Attenuation phase pathway
REACT_243409
trans-Golgi Network Vesicle Budding pathway
REACT_234979
Clathrin derived vesicle budding pathway
REACT_233572
Gene Expression pathway
REACT_259290
Neuronal System pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_222185
Regulation of HSF1-mediated heat shock response pathway
REACT_233318
Transmission across Chemical Synapses pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
hsa04010
MAPK signaling pathway pathway
hsa04612
Antigen processing and presentation pathway
hsa04144
Endocytosis pathway
hsa03040
Spliceosome pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05145
Toxoplasmosis pathway
mmu04612
Antigen processing and presentation pathway
mmu04010
MAPK signaling pathway pathway
mmu04144
Endocytosis pathway
mmu03040
Spliceosome pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
mmu05145
Toxoplasmosis pathway
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.12309
RefSeq NM_174345
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca