InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SLC26A3

Summary

InnateDB Gene

IDBG-632257.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A3

Gene Name

chloride anion exchanger

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015547

Encoded Proteins

IDBP-683869

chloride anion exchanger

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091138:
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:49058943-49092515

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000033777

ENSBTAP00000033686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity

Biological Process

GO:0006821	chloride transport
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0048240	sperm capacitation
GO:0051454	intracellular pH elevation
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071320	cellular response to cAMP
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport