Bos taurus Gene: SLC26A3
Summary
InnateDB Gene IDBG-632257.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A3
Gene Name chloride anion exchanger
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015547
Encoded Proteins
chloride anion exchanger
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091138:
The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:49058943-49092515
Strand Reverse strand
Band
Transcripts
ENSBTAT00000033777 ENSBTAP00000033686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
Biological Process
GO:0006821 chloride transport
GO:0008272 sulfate transport
GO:0015701 bicarbonate transport
GO:0048240 sperm capacitation
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0071320 cellular response to cAMP
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097225 sperm midpiece
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Multifunctional anion exchangers pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
Multifunctional anion exchangers pathway
SLC-mediated transmembrane transport pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
Transmembrane transport of small molecules pathway
KEGG
Pancreatic secretion pathway
Pancreatic secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1N207
UniProt Splice Variant
Entrez Gene 512856
UniGene Bt.9886
RefSeq NM_001083676
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02010594
GenPept
RNA Seq Atlas 512856
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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