Homo sapiens Gene: SLC26A3
Summary
InnateDB Gene IDBG-35753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A3
Gene Name solute carrier family 26, member 3
Synonyms CLD; DRA;
Species Homo sapiens
Ensembl Gene ENSG00000091138
Encoded Proteins
solute carrier family 26, member 3
solute carrier family 26, member 3
solute carrier family 26, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:107765467-107803225
Strand Reverse strand
Band q31.1
Transcripts
ENST00000340010 ENSP00000345873
ENST00000379083 ENSP00000368375
ENST00000453332 ENSP00000395955
ENST00000469651
ENST00000468551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0007588 excretion
GO:0008272 sulfate transport
GO:0015701 bicarbonate transport
GO:0048240 sperm capacitation
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0071320 cellular response to cAMP
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0097225 sperm midpiece
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Multifunctional anion exchangers pathway
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
SLC-mediated transmembrane transport pathway
KEGG
Pancreatic secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.1650
RefSeq NM_000111 XM_006715873
HUGO
OMIM
CCDS CCDS5748
HPRD 00544
IMGT
EMBL
GenPept
RNA Seq Atlas