Version 5.4
Bos taurus Gene: BT.39186
Summary
InnateDB Gene IDBG-632384.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.39186
Gene Name phosphomevalonate kinase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017819
Encoded Proteins
IDBP-683989
phosphomevalonate kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163344:
This gene encodes a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of this protein is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:15715719-15725510
Strand Forward strand
Band
Transcripts
ENSBTAT00000023689 ENSBTAP00000023689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004631 phosphomevalonate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006695 cholesterol biosynthetic process
GO:0016126 sterol biosynthetic process
GO:0016310 phosphorylation
GO:0070723 response to cholesterol
Cellular Component
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163344
View Gene Order
ENSMUSG00000027952
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_9405
Cholesterol biosynthesis pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
REACT_198969
Activation of gene expression by SREBF (SREBP) pathway
REACT_198968
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_208531
Cholesterol biosynthesis pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
hsa04146
Peroxisome pathway
mmu00900
Terpenoid backbone biosynthesis pathway
mmu04146
Peroxisome pathway
INOH
INOH website
Steroids metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.39186
RefSeq NM_001046151
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca