InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PDCD6

Summary

InnateDB Gene

IDBG-632598.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD6

Gene Name

programmed cell death protein 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000046493

Encoded Proteins

IDBP-684221

programmed cell death 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000249915:
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is also located on the short arm of chromosome 5. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:71916825-71932650

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000064656

ENSBTAP00000055204

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004198	calcium-dependent cysteine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0048306	calcium-dependent protein binding
GO:0060090	binding, bridging

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006508	proteolysis
GO:0006886	intracellular protein transport
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010595	positive regulation of endothelial cell migration
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007	negative regulation of TOR signaling
GO:0034605	cellular response to heat
GO:0036324	vascular endothelial growth factor receptor-2 signaling pathway
GO:0045766	positive regulation of angiogenesis
GO:0051592	response to calcium ion
GO:0051898	negative regulation of protein kinase B signaling

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0031410	cytoplasmic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Homo sapiens

Gene ID

Gene Order

ENSMUSG00000021576

View Gene Order

ENSG00000249915

View Gene Order

Cross-References

SwissProt

TrEMBL

Q1LZ81

UniProt Splice Variant

Entrez Gene

100125927

UniGene

RefSeq

NM_001105497 XM_005221655

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC116154 DAAA02051474

GenPept

AAI16155

RNA Seq Atlas

100125927

Transcript Frequencies

Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

(Move your mouse over the image to view a more detailed version)