Version 5.4
Bos taurus Gene: YWHAE
Summary
InnateDB Gene IDBG-632682.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAE
Gene Name 14-3-3 protein epsilon
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005664
Encoded Proteins
IDBP-684309
14-3-3 protein epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20462248
[Homo sapiens] YWHAE (14-3-3 epsilon) interacts with key components of mitogen-activated protein kinase (MAPK)signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108953:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:23086308-23121103
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007442 ENSBTAP00000007442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 347 interaction(s) predicted by orthology.
Predicted by orthology
Total 347 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023026 MHC class II protein complex binding
GO:0042826 histone deacetylase binding
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0050815 phosphoserine binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001764 neuron migration
GO:0006605 protein targeting
GO:0021762 substantia nigra development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0035308 negative regulation of protein dephosphorylation
GO:0060306 regulation of membrane repolarization
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1902309 negative regulation of peptidyl-serine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000108953
View Gene Order
ENSMUSG00000020849
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223914
G2/M Transition pathway
REACT_218726
Regulation of HSF1-mediated heat shock response pathway
REACT_219199
Activation of BH3-only proteins pathway
REACT_206069
Cellular responses to stress pathway
REACT_217718
Translocation of GLUT4 to the plasma membrane pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_205006
Loss of Nlp from mitotic centrosomes pathway
REACT_217933
Mitotic G2-G2/M phases pathway
REACT_211402
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_214934
Cell Cycle pathway
REACT_214353
Signal Transduction pathway
REACT_217273
HSF1 activation pathway
REACT_214350
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_222195
Intrinsic Pathway for Apoptosis pathway
REACT_207066
Signalling by NGF pathway
REACT_225257
Cellular response to heat stress pathway
REACT_224179
NADE modulates death signalling pathway
REACT_219580
Activation of BAD and translocation to mitochondria pathway
REACT_224118
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_218183
p75 NTR receptor-mediated signalling pathway
REACT_215812
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_210400
Centrosome maturation pathway
REACT_217897
Signaling by Hippo pathway
REACT_219454
Apoptosis pathway
REACT_213260
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_9
TNFalpha pathway
NetPath_10
Hedgehog pathway
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_13526
NADE modulates death signalling pathway
REACT_118607
Signaling by Hippo pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_120956
Cellular responses to stress pathway
REACT_11061
Signalling by NGF pathway
REACT_200780
Regulation of HSF1-mediated heat shock response pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_200819
Cellular response to heat stress pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_200744
HSF1 activation pathway
REACT_11123
Membrane Trafficking pathway
REACT_245720
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_258521
Apoptosis pathway
REACT_240530
G2/M Transition pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_243078
Loss of Nlp from mitotic centrosomes pathway
REACT_209837
Membrane Trafficking pathway
REACT_188957
Cellular responses to stress pathway
REACT_188804
Cell Cycle pathway
REACT_221775
Activation of BAD and translocation to mitochondria pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_204413
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_210754
NADE modulates death signalling pathway
REACT_224790
Cellular response to heat stress pathway
REACT_244487
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_196537
Signaling by Hippo pathway
REACT_196635
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_248921
Signalling by NGF pathway
REACT_225256
HSF1 activation pathway
REACT_212161
Activation of BH3-only proteins pathway
REACT_188257
Signal Transduction pathway
REACT_222185
Regulation of HSF1-mediated heat shock response pathway
REACT_210847
p75 NTR receptor-mediated signalling pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_253753
Centrosome maturation pathway
REACT_204001
Intrinsic Pathway for Apoptosis pathway
KEGG
hsa04110
Cell cycle pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04114
Oocyte meiosis pathway
mmu04110
Cell cycle pathway
mmu04722
Neurotrophin signaling pathway pathway
mmu04114
Oocyte meiosis pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
Fas signaling pathway pathway
INOH website
Wnt signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
Fas signaling pathway pathway
PID NCI
igf1_pathway
IGF1 pathway
p75ntrpathway
p75(NTR)-mediated signaling
hdac_classii_pathway
Signaling events mediated by HDAC Class II
tgfbrpathway
TGF-beta receptor signaling
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
telomerasepathway
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4035 Bt.64792
RefSeq NM_174491
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca