Bos taurus Gene: YWHAE
Summary
InnateDB Gene IDBG-632682.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAE
Gene Name 14-3-3 protein epsilon
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000005664
Encoded Proteins
14-3-3 protein epsilon
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] YWHAE (14-3-3 epsilon) interacts with key components of mitogen-activated protein kinase (MAPK)signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108953:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100%% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:23086308-23121103
Strand Reverse strand
Band
Transcripts
ENSBTAT00000007442 ENSBTAP00000007442
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 347 interaction(s) predicted by orthology.
Predicted by orthology
Total 347 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0023026 MHC class II protein complex binding
GO:0042826 histone deacetylase binding
GO:0044325 ion channel binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0050815 phosphoserine binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0001764 neuron migration
GO:0006605 protein targeting
GO:0021762 substantia nigra development
GO:0021766 hippocampus development
GO:0021987 cerebral cortex development
GO:0035308 negative regulation of protein dephosphorylation
GO:0060306 regulation of membrane repolarization
GO:1901016 regulation of potassium ion transmembrane transporter activity
GO:1902309 negative regulation of peptidyl-serine dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
G2/M Transition pathway
Regulation of HSF1-mediated heat shock response pathway
Activation of BH3-only proteins pathway
Cellular responses to stress pathway
Translocation of GLUT4 to the plasma membrane pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Mitotic G2-G2/M phases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Cell Cycle pathway
Signal Transduction pathway
HSF1 activation pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Intrinsic Pathway for Apoptosis pathway
Signalling by NGF pathway
Cellular response to heat stress pathway
NADE modulates death signalling pathway
Activation of BAD and translocation to mitochondria pathway
Regulation of PLK1 Activity at G2/M Transition pathway
p75 NTR receptor-mediated signalling pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Centrosome maturation pathway
Signaling by Hippo pathway
Apoptosis pathway
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
TNFalpha pathway
Hedgehog pathway
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
NADE modulates death signalling pathway
Signaling by Hippo pathway
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
Cellular responses to stress pathway
Signalling by NGF pathway
Regulation of HSF1-mediated heat shock response pathway
p75 NTR receptor-mediated signalling pathway
Apoptosis pathway
Signal Transduction pathway
Cell Cycle pathway
Activation of BH3-only proteins pathway
Centrosome maturation pathway
G2/M Transition pathway
Cellular response to heat stress pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
Cell Cycle, Mitotic pathway
Intrinsic Pathway for Apoptosis pathway
Mitotic G2-G2/M phases pathway
HSF1 activation pathway
Membrane Trafficking pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Apoptosis pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Loss of Nlp from mitotic centrosomes pathway
Membrane Trafficking pathway
Cellular responses to stress pathway
Cell Cycle pathway
Activation of BAD and translocation to mitochondria pathway
Mitotic G2-G2/M phases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NADE modulates death signalling pathway
Cellular response to heat stress pathway
Loss of proteins required for interphase microtubule organization√?¬†from the centrosome pathway
Signaling by Hippo pathway
Regulation of PLK1 Activity at G2/M Transition pathway
Signalling by NGF pathway
HSF1 activation pathway
Activation of BH3-only proteins pathway
Signal Transduction pathway
Regulation of HSF1-mediated heat shock response pathway
p75 NTR receptor-mediated signalling pathway
Translocation of GLUT4 to the plasma membrane pathway
Centrosome maturation pathway
Intrinsic Pathway for Apoptosis pathway
KEGG
Cell cycle pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
Cell cycle pathway
Neurotrophin signaling pathway pathway
Oocyte meiosis pathway
INOH
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
PID NCI
IGF1 pathway
p75(NTR)-mediated signaling
Signaling events mediated by HDAC Class II
TGF-beta receptor signaling
Lissencephaly gene (LIS1) in neuronal migration and development
Regulation of Telomerase
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.4035 Bt.64792
RefSeq NM_174491
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas