InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MYO1C

Summary

InnateDB Gene

IDBG-632689.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO1C

Gene Name

Unconventional myosin-Ic

Synonyms

MMIb

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001332

Encoded Proteins

IDBP-684382

Myosin-Ic

IDBP-684388

Myosin-Ic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197879:
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:23168435-23191280

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000029555	ENSBTAP00000029554
ENSBTAT00000029554	ENSBTAP00000029553

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding

Biological Process

GO:0006605	protein targeting
GO:0006612	protein targeting to membrane
GO:0006810	transport
GO:0008152	metabolic process
GO:0015031	protein transport
GO:0030335	positive regulation of cell migration
GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0051028	mRNA transport
GO:0090314	positive regulation of protein targeting to membrane
GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0016459	myosin complex
GO:0031410	cytoplasmic vesicle
GO:0031941	filamentous actin
GO:0032420	stereocilium
GO:0042995	cell projection
GO:0045121	membrane raft
GO:0045160	myosin I complex
GO:0060171	stereocilium membrane
GO:0070062	extracellular vesicular exosome