Version 5.4
Homo sapiens Gene: MYO1C
Summary
InnateDB Gene IDBG-14745.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYO1C
Gene Name myosin IC
Synonyms MMI-beta; MMIb; myr2; NMI
Species Homo sapiens
Ensembl Gene ENSG00000197879
Encoded Proteins
IDBP-14749
myosin IC
IDBP-14751
myosin IC
IDBP-360897
myosin IC
IDBP-587370
myosin IC
IDBP-759526
IDBP-758075
IDBP-759262
IDBP-764011
IDBP-763580
IDBP-764191
IDBP-760816
IDBP-763346
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:1464098-1492812
Strand Reverse strand
Band p13.3
Transcripts
ENST00000359786 ENSP00000352834
ENST00000361007 ENSP00000354283
ENST00000438665 ENSP00000412197
ENST00000545534 ENSP00000437685
ENST00000574308
ENST00000571615
ENST00000574790 ENSP00000461175
ENST00000575158 ENSP00000459174
ENST00000574341
ENST00000575864
ENST00000575335 ENSP00000460415
ENST00000571851
ENST00000572615
ENST00000573961
ENST00000571715 ENSP00000458610
ENST00000573198
ENST00000575011 ENSP00000459558
ENST00000576822
ENST00000570984 ENSP00000459271
ENST00000573853 ENSP00000460831
ENST00000570490 ENSP00000461682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 46 [view]
Protein-Protein 46 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0030898 actin-dependent ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006605 protein targeting
GO:0006612 protein targeting to membrane
GO:0006810 transport
GO:0008152 metabolic process
GO:0030335 positive regulation of cell migration
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
GO:0051028 mRNA transport
GO:0061024 membrane organization
GO:0090314 positive regulation of protein targeting to membrane
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005903 brush border
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016328 lateral plasma membrane
GO:0016459 myosin complex
GO:0016461 unconventional myosin complex
GO:0031941 filamentous actin
GO:0032420 stereocilium
GO:0045121 membrane raft
GO:0045160 myosin I complex
GO:0060171 stereocilium membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017774
View Gene Order
ENSBTAG00000001332
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.286226 Hs.631245
RefSeq NM_001080779 NM_001080950 NM_033375 XM_005256655
HUGO
OMIM
CCDS CCDS11003 CCDS42226 CCDS45562
HPRD 09411
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca