Bos taurus Gene: BOLA-DQB
Summary
InnateDB Gene IDBG-632854.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BOLA-DQB
Gene Name boLa class II histocompatibility antigen, DQB*0101 beta chain precursor
Synonyms BoLA-DQB; DQB; DQB1; OLA-DQB;
Species Bos taurus
Ensembl Gene ENSBTAG00000019588
Encoded Proteins
BOLA class II histocompatibility antigen, DQB*0101 beta chain precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] H2-Ab1 is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179344:
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:25855146-25863045
Strand Reverse strand
Band
Transcripts
ENSBTAT00000026100 ENSBTAP00000026100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042613 MHC class II protein complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
PD-1 signaling pathway
Phosphorylation of CD3 and TCR zeta chains pathway
Downstream TCR signaling pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
MHC class II antigen presentation pathway
Translocation of ZAP-70 to Immunological synapse pathway
Costimulation by the CD28 family pathway
Interferon gamma signaling pathway
Interferon Signaling pathway
Adaptive Immune System pathway
Generation of second messenger molecules pathway
TCR signaling pathway
KEGG
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
Phagosome pathway
Cell adhesion molecules (CAMs) pathway
Antigen processing and presentation pathway
Intestinal immune network for IgA production pathway
Type I diabetes mellitus pathway
Leishmaniasis pathway
Toxoplasmosis pathway
Staphylococcus aureus infection pathway
Asthma pathway
Autoimmune thyroid disease pathway
Systemic lupus erythematosus pathway
Allograft rejection pathway
Graft-versus-host disease pathway
Viral myocarditis pathway
INOH
CD4 T cell receptor signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1N610 G9HQR0
UniProt Splice Variant
Entrez Gene 790858
UniGene
RefSeq NM_001034668
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02055305 DAAA02055306 JN383615
GenPept AEW46229
RNA Seq Atlas 539241 790858