Version 5.4
Homo sapiens Gene: HLA-DQB1
Summary
InnateDB Gene IDBG-81203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HLA-DQB1
Gene Name major histocompatibility complex, class II, DQ beta 1
Synonyms CELIAC1; HLA-DQB; IDDM1
Species Homo sapiens
Ensembl Gene ENSG00000179344
Encoded Proteins
IDBP-81205
major histocompatibility complex, class II, DQ beta 1
IDBP-231497
major histocompatibility complex, class II, DQ beta 1
IDBP-231499
major histocompatibility complex, class II, DQ beta 1
IDBP-231501
major histocompatibility complex, class II, DQ beta 1
IDBP-374576
major histocompatibility complex, class II, DQ beta 1
IDBP-603290
major histocompatibility complex, class II, DQ beta 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21441935
[Mus musculus] H2-Ab1 is an intracellular MHC class II molecule that can act as an adaptor to promote the full activation of the TLR-triggered innate immune response.
Entrez Gene
Summary HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32659467-32668383
Strand Reverse strand
Band p21.32
Transcripts
ENST00000374943 ENSP00000364080
ENST00000399084 ENSP00000382034
ENST00000399082 ENSP00000382032
ENST00000399079 ENSP00000382029
ENST00000434651 ENSP00000407332
ENST00000487676
ENST00000484729 ENSP00000436686
ENST00000460185
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0045087 innate immune response
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042612 MHC class I protein complex
GO:0042613 MHC class II protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073421
View Gene Order
ENSBTAG00000019588
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04612
Antigen processing and presentation pathway
hsa04940
Type I diabetes mellitus pathway
hsa05330
Allograft rejection pathway
hsa05320
Autoimmune thyroid disease pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05332
Graft-versus-host disease pathway
hsa05310
Asthma pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05416
Viral myocarditis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05145
Toxoplasmosis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.560366 Hs.697180 Hs.697652
RefSeq NM_001243961 NM_002123
HUGO
OMIM
CCDS CCDS43451 CCDS59006
HPRD 05054
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca