InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PGD

Summary

InnateDB Gene

IDBG-633131.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGD

Gene Name

6-phosphogluconate dehydrogenase, decarboxylating

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000013527

Encoded Proteins

IDBP-684816

phosphogluconate dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142657:
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:44043496-44058198

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000017988

ENSBTAP00000017988

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491	oxidoreductase activity
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661	NADP binding
GO:0050662	coenzyme binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0009051	pentose-phosphate shunt, oxidative branch
GO:0019322	pentose biosynthetic process
GO:0055114	oxidation-reduction process