Version 5.4
| Bos taurus Gene: SH2B3 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-633193.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | SH2B3 | ||||||||
| Gene Name | SH2B adapter protein 3 | ||||||||
| Synonyms | |||||||||
| Species | Bos taurus | ||||||||
| Ensembl Gene | ENSBTAG00000009101 | ||||||||
| Encoded Proteins |
SH2B adaptor protein 3
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111252:
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus.[provided by RefSeq, May 2010] This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 17:57398014-57422729 | ||||||||
| Strand | Forward strand | ||||||||
| Band | |||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||||
| NETPATH |
KitReceptor pathway
TCR pathway
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| REACTOME |
Factors involved in megakaryocyte development and platelet production pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Hemostasis pathway
Hemostasis pathway
Regulation of KIT signaling pathway
Signaling by SCF-KIT pathway
Factors involved in megakaryocyte development and platelet production pathway
Signal Transduction pathway
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| KEGG |
Neurotrophin signaling pathway pathway
Neurotrophin signaling pathway pathway
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| INOH | |||||||||
| PID NCI |
EPO signaling pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
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| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | E1BE90 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 614726 | ||||||||
| UniGene | Bt.91558 | ||||||||
| RefSeq | NM_001193067 XM_005217911 | ||||||||
| HUGO | HGNC:29605 | ||||||||
| OMIM | |||||||||
| CCDS | |||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | DAAA02045291 | ||||||||
| GenPept | |||||||||
| RNA Seq Atlas | 614726 | ||||||||