Bos taurus Gene: ALDH8A1
InnateDB Gene IDBG-633488.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH8A1
Gene Name Aldehyde dehydrogenase family 8 member A1
Species Bos taurus
Ensembl Gene ENSBTAG00000007975
Encoded Proteins
aldehyde dehydrogenase family 8 member A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118514:
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:73977645-74002359
Strand Reverse strand
ENSBTAT00000010485 ENSBTAP00000010485
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001758 retinal dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Biological Process
GO:0008152 metabolic process
GO:0042573 retinoic acid metabolic process
GO:0042574 retinal metabolic process
GO:0042904 9-cis-retinoic acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Homo sapiens
Mus musculus
Gene ID
Gene Order
SwissProt Q0P5F9
UniProt Splice Variant
Entrez Gene 513537
UniGene Bt.43302
RefSeq NM_001075626
EMBL BC120092 BT029881
GenPept AAI20093 ABM06132
RNA Seq Atlas 513537