Version 5.4
Bos taurus Gene: STEAP2
Summary
InnateDB Gene IDBG-633853.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STEAP2
Gene Name metalloreductase STEAP2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000003506
Encoded Proteins
IDBP-685587
metalloreductase STEAP2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157214:
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:74886596-74911776
Strand Forward strand
Band
Transcripts
ENSBTAT00000004557 ENSBTAP00000004557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008823 cupric reductase activity
GO:0052851 ferric-chelate reductase (NADPH) activity
Biological Process
GO:0006893 Golgi to plasma membrane transport
GO:0006897 endocytosis
GO:0009725 response to hormone
GO:0015677 copper ion import
GO:0045055 regulated secretory pathway
GO:0055114 oxidation-reduction process
GO:0097461 ferric iron import into cell
Cellular Component
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0030140 trans-Golgi network transport vesicle
GO:0030173 integral component of Golgi membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000157214
View Gene Order
ENSMUSG00000015653
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25283
Transferrin endocytosis and recycling pathway
REACT_25060
Iron uptake and transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL A0JNK9
UniProt Splice Variant
Entrez Gene 504616
UniGene Bt.46419
RefSeq NM_001077847
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC126751 DAAA02011063
GenPept AAI26752
RNA Seq Atlas 504616

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca